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Data availability The data that support the findings of this study are openly available in TCGA database of PTCs utilizing the Firehouse web browser from the Broad Institute ( using TIMER2.0 ( a computational software for analyses of tumor immunologic, clinical, and genomic features 35

Anti-inflammatory Signalling Downregulates inflammatory cytokines at injury sites, supporting faster resolution of acute inflammation during the repair cascade

However, the specific subcellular compartment in which the GCH1-BH4 system works remains to be determined

Theoretical insights into the mechanism for thiol/disulfide exchange