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The Coq9 R239X mouse model, which has a severe reduction in CoQ levels and suffers a fatal mitochondrial encephalopathy, has severe reduction in the levels and activity of SQOR in the brain, kidneys and skeletal muscle [75], and, as a consequence, the CBS levels are increased [64]

Moreover, the differential responses of the OL lineage in white vs gray matter, particularly in the context of remyelination, suggests the importance of considering distinct regional responses of OLs to therapeutics

Future Research Directions for Longevity Peptide Therapeutics MOTS-c represents an intriguing example of mitochondrial signaling with measurable human biomarker data