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GSH deficiency or a decrease in the GSH/glutathione disulfide (GSSG) ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in diseases such as cancer, Parkinsons disease, and Alzheimers disease

All the research and its results, based on the various lines of evidence including in vitro and in vivo studies and clinical trials, will help encourage the discovery and development of specific agents with potential therapeutic values to be further investigated/developed as effective drug candidates, also considering the dose, duration, and mechanism of action and potential targets of these components

Alarcn et al., 2015)

Noncoding microdeletion in mouse Hgf disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39