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In this context, SAM administration may act as a precursor for GSH synthesis and also bypass the deficiency in SAM synthetase

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Wang J.Q., Yang Y., Cai C.Y., Teng Q.X., Cui Q., Lin J., Assaraf Y.G., Chen Z.S

This has led to the concept of a nuclear redox cycle that occurs during mitosis in which GSH moves into the nucleus during G1, promoting oxidation of the cytosol and enhanced glutathione accumulation (Diaz-Vivancos et al., 2010b)

Recent advancements, including deep tissue fluorescence imaging, metabolomics, and mass spectrometry imaging, have enabled in vivo investigations of redox mechanisms in tumors, 526 but further research is needed to achieve full precision and efficacy