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Melatonin has also been shown to be effective at the cardiovascular level in lowering blood pressure in humans, type 1 diabetic adolescents (Cavallo et al., Another study showed that melatonin is a valuable therapeutic agent against ischemic stroke related to aging, demonstrating that aged Wistar rats treated with melatonin from 24 h prior to until 7 days after an induced ischemic stroke had a significant reduction in the concentrations of glial fibrillary acidic protein, TNF-, IL-1, Bcl-2-associated death promoter, and Bcl-2-associated X protein in both the hippocampus and brain cortex, while the hippocampal concentrations of sirtuin 1 and Bcl-2 were increased