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This mechanism is also essential in sequestering and subsequent removal of abnormal organic acids in several organic acidemia [8]
Welch, W
J Neurochem 110:16741684 Penkowa M, Srensen BL, Nielsen SL, Hansen PB (2009) Metallothionein as a useful marker in Hodgkin lymphoma subclassification
Initial clinical trials only tested a gap of less than six months between doses, but unexpected popularity and resulting shortages caused further testing to validate wider spacing of the two doses