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Men in the dutasteride group experienced 22.8% less incidence of biopsy-proven prostate cancer dutasteride group, as compared with placebo group, but no significant difference was found in the frequency of high-grade disease [4]

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The presence of an extra X chromosome (Klinefelter syndrome) or an extra Y chromosome, the presence of two X but no Y chromosome in a male, and microdeletions or translocations affecting the X or Y chromosome are examples of chromosomal problems that can disrupt sperm production and overall genital and gonad development, resulting in azoospermia (absence of sperm) and infertility