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[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration

Trebatick, J., Kopasov, S., Hraden, Z., inovsk, K., kodek, I., uba, J., Muchov, J., itanov, I., Waczulkov, I., Rohdewald, P., & urakov, Z

If any of the genes involved in this pathway contain single nucleotide polymorphisms (SNPs) that affect the function of the enzyme, it can cause dysfunction in the processing

For example, many children with ASD are found to be deficient in vitamin D, calcium, and magnesium, whereas some may consume excessive vitamin A, zinc, or folic acid through supplements