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Description
Rodriguez NM, Shackelford K

Marques de Brito et al., 2023)

Cagrilintide was engineered with a C18 fatty diacid modification that enables albumin binding and extends its pharmacokinetic half-life, allowing for once-weekly subcutaneous dosing in clinical studies

The classic Bouwstra model describes the layer as a brick-and-mortar arrangement: corneocytes (the "bricks") are tightly packed flattened cells held together by intercellular lipids (the "mortar") arranged in lamellar bilayers
