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While beta-3 receptor density varies between fat depots (higher in visceral, moderate in abdominal subcutaneous, lower in gluteal-femoral), the peptide works systemically

At first glance, it may seem like higher oral doses would work better, but evidence suggests that is not always true

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Although the exact mechanism for this weight-reducing effect is unknown, the proposed mechanism includes alterated perception of taste due to carbonic anhydrase activity and modulation of dopamine and serotonin levels in the brain [241, 244, 245].Empatic has shown promising results in phase 2 clinical trials [241] (Table 2 )