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Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

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Additionally, the GSH content was significantly reduced in the substantia nigra of PD patients, suggesting that GSH depletion enhances neuronal death under certain pathological conditions [6]

Neuro Endocrinol Lett 32(2):133140 Maes M, Fiar Z, Medina M et al (2012) New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways