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Inhibition of GCH1 reduced BH4 and resulted in enhanced erastin-induced iron accumulation and lipid peroxidation, thereby enhancing ferroptosis sensitivity, while BH4 supplementation suppressed ferroptosis-related changes caused by GCH1 downregulation
10.7812/TPP/19.200 51 ChengP.ZargaranA.RajabaliF.TurcotteK.BabulS

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doi: 10.1158/0008-5472.CAN-05-1107