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These challenges can be met by nucleotide modifications and choosing conjugates with appropriate molecular weight and positive charge [213, 214]

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Li Z, Wermuth PJ, Benn BS, Lisanti MP, Jimenez SA (2013) Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro

While acetaminophen alone is not effective for severe pain, it is combined with nonsteroidal anti-inflammatory drugs (NSAIDs) to provide stronger relief without the risks associated with opioid-based medications