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Targeting Aging with Metformin (TAME)

Arch Endocrinol Metab 69:e230348 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Shi Z, Han Z, Chen J, Zhou J-C (2024) Endoplasmic reticulum-resident selenoproteins and their roles in glucose and lipid metabolic disorders

Mfn2 deficiency in the kidney causes mitochondrial fragmentation without affecting renal tubular function during development or under non-stress conditions

Older individuals produce by a lot less glutathione, which creates increased oxidative stress and cellular damage
