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Research models where BPC-157 showed activity: Esophageal, gastric, and duodenal ulcers NSAID-induced small intestinal damage Colonic inflammation and ulceration Post-surgical anastomosis healing GI fistula closure In anastomosis research, BPC-157 improved healing in esophagogastric, jejunoileal, and colocolonic surgical connections

[DOI] [PMC free article] [PubMed] [Google Scholar] 273.Sampath V, Caughey WS

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[41] Contraindications [edit] Pregnancy and lactation [edit] Use of tramadol during pregnancy is generally avoided, as it may cause some reversible withdrawal effects in the newborn