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The G-protein coupled receptor GPR39, which is also called zinc receptor (ZnR) because it links fluctuations of extracellular zinc to calcium signaling in cells, regulates intestinal ion transport and barrier function in epithelial cells and has been implicated in modulating insulin signaling, fibrosis, and inflammation of the liver [57]

Funding This article is funded by Shandong Province's Traditional Chinese Medicine Science and Technology Development Project (grant no

and glutathione S-transferase pi 1, GSTP1 , rs4147581 were genotyped by TaqMan-based allelic discrimination assay (Applied Biosystems, USA) using a CFX96 Touch Real-Time PCR detection system (Bio-Rad, USA)

Furthermore, MnO can be selectively reduced by reducing agents such as ascorbic acid (AA), enabling controllable modulation of catalytic and optical properties