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Many SARS-CoV-2 VoCs exhibit convergent evolution of mutations concentrated around the RBD, NTD and polybasic furin cleavage site of spike protein that enhance immune evasion by reducing antibody binding and/or promoting transmissibility, thereby promoting overall fitness 106

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In healthy individuals, long-term use might diminish the guts intrinsic ability to self-regulate, reducing colonization resistance against pathogens like Chloridoids difficile or Salmonella (52, 200, 201)

The sensor chip was prepared by a 10-min regeneration step with a solution composed of 50 mM NaOH and 1 M NaCl followed by three 30-s regeneration steps with 10 mM glycine-HCl (pH 2.0)