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Thus, under the above conditions protein phosphatases are activated [37], dephosphorylate AMPA-Rs, and induce the removal of AMPA-Rs from the postsynaptic membrane [38], thereby reducing the postsynaptic responsiveness to glutamate and leading to LTD

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The compound was developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam) and published in a landmark 2017 Cell paper (Baar et al., Cell 169:132-147) demonstrating selective induction of apoptosis in cellular senescence research models