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In: Fu H (editor), Protein-Protein Interactions, Methods and Applications, Methods in Molecular Biology, 261

A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

That most anti-cancer drugs are poor substrates for GSTP indicates that the role of elevated GSTP in many tumor cell lines is not to detoxify the compounds, but must have another purpose