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Side effects with NAC supplements include gastrointestinal symptoms, which occur in up to 23% of patients.[ref] While generally safe at supplemental doses, a drawback to N-acetyl cysteine is the sulfur smell and taste

10.1111/j.1462-5822.2006.00836.x Summary Keywords gut microbiota, intestinal barrier, gut-brain axis, depression, probiotics, psychobiotics Citation Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G and Hyland NP (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Psychiatrist role involves taper design, medication adjustments, evaluating whether symptoms are withdrawal or relapse, and deciding when reinstatement or a slower taper is appropriate

Inhibition of ASK1 activity significantly inhibits the development of NASH