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20.528 min: hold at 20% B at a 0.150 mL/min flow rate

Mientras que el efecto protector del folato contra DTN est bien establecido, solo unos pocos estudios han investigado el papel de otros donantes de grupos metilo, incluyendo colina y betana, en la aparicin de DTNs

Serum liver tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months [see Warnings and Precautions (5.1)]
