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This glutathione depletion is not merely a consequence of the disease - it is thought to be a contributing driver of disease progression, creating a vicious cycle: oxidative stress depletes glutathione reduced glutathione allows more oxidative damage more protein oxidation stronger autoimmune response more thyroid destruction more oxidative stress

Environ Pollut 1(270):116227 Wang F, Li Y, Tang D et al (2023) Epidemiological analysis of drinking water-type fluorosis areas and the impact of fluorosis on childrens health in the past 40 years in China

The best illustration of this fact is given by X-ray crystallography, which serves as the primary tool for determining the 3D atomic structure of proteins