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Description
Cigarette smoke can reduce the expression of Frizzled receptor 4 (FZD4) in alveolar epithelial cells and enhance the phosphorylation of -catenin, inhibiting epithelial proliferation and alveolar repair mediated by the classic Wnt signalling pathway

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elegans , PARP inhibition results in a significant lifespan extension in wild-type worms 190 , in a model of ataxia telangiectasia 135 and under hyperglycaemic conditions 221

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