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doi: 10.1186/1475-2891-13-20 111 Wachtel-GalorS.BenzieI

In the nervous system, inhibition of mTOR pathway, including its downstream effectors p70S6K and 4E-BP1, usually promotes neuronal apoptosis 11

A 2000 study involving obese Zucker rats concluded that Fragment 176-191 did not negatively impact insulin sensitivity [11], while a 2001 study involving obese mice found that insulin secretion was unaffected [12]

FIGURE 3 7.1 Flavonoids: multitarget antioxidants and metabolic regulators Flavonoids exert hepatoprotective effects through synergistic mechanisms that include direct ROS scavenging, activation of antioxidant pathways, and metabolic regulation