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CYT-6091 clinical trials started in 2005 for delivery of recombinant TNF- as an anticancer therapy in late-stage pancreatic, breast, colon, melanoma, sarcoma and lung cancer patients
In a human study administration of silymarin (210 mg/day) for 8 weeks in peritoneal dialysis patients inhibited the effects of pro-inflammatory cytokines especially TNF- (47)
Tachykinins also enhance eosinophils chemotaxis through the activation of alveolar macrophages and monocytes that release inflammatory cytokines such as IL-6
