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Secondly, motivated by the need for a more relevant measure of destructive brain pathology, AVONEX clinical trial investigators pre-specified brain atrophy as an exploratory measure, and applied a new highly precise measure of brain atrophy, the so-called brain parenchymal fraction, to images collected during the trial
Currently, there are several candidates that successfully passed different clinical phases of drug development, with different pharmacological targets to palliate ASD behavioral and neurological symptoms (Table 2, Figure 3)
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R., Shea, L
