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Oral tablets are also convenient to take compared to injectables
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Long-term opioid therapy often leads to reduced analgesic efficacy, requiring higher doses that increase the risk of dependency and adverse effects [79]
Additionally, they increased the response and functionality of regulatory T cells, due to their direct role in stimulating the synthesis of anti-inflammatory cytokines such as interleukin 10 (IL-10) and transforming growth factor beta (TGF-)[6]
