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Characteristics of the included trials In total, twenty-two randomised trials with 1710 participants proved eligible for inclusion in the present meta-analysis (Reference Ahmed Al-Naggar, Osman and Abdulghani23Reference Wedick, Brennan and Sun44) (Table 1)

The inhibition of specific HDAC isoforms has shown therapeutic promise in AD models, improving cognitive function and reducing pathological hallmarks 30

A clinical trial study suggests that NAC promotes early neurological recovery in patients with ischemic stroke (Komakula et al., 2024)

Clinical investigation of GLS inhibition has instead focused on optimized agents such as CB-839 [165,166]