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17,18 Furthermore, no novel therapies have received approval in recent years

Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

Many theories tried to explain how the virus enters the brain and its impact on it [2]

Cancers 9 , 32 (2017)
