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T., Gonzales, F
Figure 3: Photograph of Linus Pauling 1941 (credit: California Institute of Technology Yearbook) with a diagram of his instructionist theory
ADRs may also occur if a drug inhibits a CYP isoenzyme and/or disrupts enzyme function in combination with other prescribed drugs, thus for instance causing an intermediate metabolizer genotype to phenotypically present as a poor metabolizer
Curcumin was also reported to inhibit EC cell migration by increasing Slit2 expression, which in turn downregulated pro-metastatic proteins like CXCR4, SDF-1, and MMP-2/9 (83)
