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Rhinacanthin C (RC), a representative quinone metabolite characterized by its distinctive conjugated double-bond structure, has achieved three groundbreaking advancements in the treatment of NAFLD: (1) Dual Regulatory Switch: RC establishes a energy sensing-epigenetic regulation dual switch mechanism through allosteric activation of the AMPK subunit (Thr172 phosphorylation 2.8-fold) and enhancement of SIRT1 activity ( 1.9-fold)

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the reported common pathophysiology of kidney disease concerns the excessive production of endogenous oxidants such as reactive nitrogen species (RNS) and reactive oxygen species (ROS) as well as inflammatory cytokines