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A randomized controlled double-blind crossover trial (Macfarlane et al., 2013) showed that combined administration of Bifidobacteria and the prebiotic inulin led to an increase in Bifidobacteria and a reduction in Proteobacteria in the host

Curcumin further reduced the release of inflammatory factors and apoptosis by inhibiting the activation of Nuclear factor kappa-B (NF-B) (Yang et al., 2025)
