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These patients warrant either baseline supplementation or at minimum testing b12 levels every 6 to 12 months during treatment to catch declining levels before deficiency develops

One mechanism involves the S-sulfhydation of OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) at Cys91, which stabilizes the Xc light chain subunit (xCT), thereby promoting cystine uptake and maintaining GSH biosynthesis [77]

We need to improve access to these medications

Statistical Analysis Univariate analyses were performed to compare fold changes, calculate the areas under the curve (AUC) and determine statistical significance