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A 'substrate-limitation' model in FM is supported by elevated homocysteine levels observed in FM/chronic fatigue syndrome cohorts, by associations between symptoms and the MTHFR C677T (rs1801133) variant, and by gene-environment interactions showing that rs1801133 modifies the effect of physical activity on fatigue
Noble M, Smith J, Power J, Mayer-Prschel M
Epilepsy, regulation of brain energy metabolism and neurotransmission
Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth
