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This guide aggregates the available rodent PK data, protocol-design implications, and known gaps

Tirzepatide, the first dual GIP/GLP-1 receptor agonist (RA), received US Food and Drug Administration (FDA) approval for the treatment of T2DM in May 2022 and for chronic weight management in November 2023 [4]

Efflux pump inhibitors (EPIs) Verapamil, a calcium channel blocker used to treat hypertension, angina, and cardiac arrhythmia [81], has been identified as an EPI with potential application in TB therapy

Further investigations are also required to isolate the bioactive compounds responsible for immunity-boosting, drug development, antioxidant, anti-inflammatory, antibiotic, and antimicrobial activities in their pure form