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Description
The endothelial cells are tightly connected by intracellular junctions that play a crucial role in maintaining the highly selective permeability of the BBB, allowing it to regulate the movement of ions, molecules, and cells between the blood and the neural tissue ( This highly selective and regulated nature of the BBB presents a significant challenge in the treatment of GB

For both compounds, more than 60% of the platinum accumulated in the cytoplasm and about 10% in the nucleus (Fig

Mitochondrial dysfunctions have been demonstrated as a key player in the development of brain stroke as evident by reduced ATP production, the starvation of glucose and oxygen to the tissues and influence on cell death pathways [157]

Environ Mol Mutagen 60(3):227242
