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It has been shown to sensitize cancer cells to chemotherapeutic agents and enhance apoptosis (Ghoneum 2005
9,19 There are no prospective randomized studies on the safety of cimetidine and other H 2 RAs during pregnancy, but the general consensus is that cimetidine and possibly famotidine are safe
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Indeed, preclinical studies conducted in renal carcinoma model reported that the VEGFR2 inhibitor sunitinib increases vascular mimicry under hypoxia by transforming tumor cells into endothelial-like cells resulting in tumor resistance [301]
