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Hajialyani M, Hosein Farzaei M, Echeverra J et al (2019) Hesperidin as a neuroprotective agent: a review of animal and clinical evidence
Metabolic abnormalities are evident in ME/CFS, such as reduced mitochondrial respiratory function in ME/CFS neutrophils (371, 375) and PBMCs (385)
Upregulated PYCR1 expression has been demonstrated to activate STAT3 phosphorylation in lung cancer, which in turn leads to elevated PD-L1 expression and subsequent inhibition of T cell infiltration [113]
In addition, there is a close functional relationship with redox metabolism
