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Assessment of reactivity of 2 and TRi-1 with N-Boc protected methyl ester of L-selenocysteine Dimethyl bis( N - tert -butoxycarbonyl)-L-selenocystine was synthesized as reported previously 85

To date, several drugs impairing glutamine metabolism have been introduced in clinical trials for various tumor types, including CRC 13

The role of lactate is to modulate neural redox state and energy metabolism, which then serves to indirectly enhance NMDA receptor activity, thus facilitating downstream calcium signaling and synaptic plasticity [100,103,105]