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Targeting prion-like protein spreading in neurodegenerative diseases

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The herb inhibits aldose reductase, which helps avoid oxidative stress, inflammatory reactions, and cellular death in retinal microglia [305]

This technology originated in the 1970s, was initially used to study the interactions between proteins and small molecules, and has now expanded to complex systems such as protein-protein and nucleic acid-ligand interactions, even applicable to larger molecules like short peptides and macrocyclic compounds (Agrawal et al., 2019