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[DOI] [PubMed] [Google Scholar] 23.Steele T.D., McCann U.D., Ricaurte G.A

When neurons die as a consequence of the removal of their targets, the phenomenon is termed retrograde trans-synaptic degeneration , and when neurons die following deafferentation, the phenomenon is termed anterograde trans-synaptic degeneration

I think now its pretty clear to me that if youre thinking about the molecular events that are leading to these hallmarks of aging, which lead to the phenotypes and frailty and the diseases like type 2 diabetes, cancer, Alzheimers disease go upstream of that, and the inflammation is at the core of it