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Simeone Radiology.2022

Borneol downregulated the expression of PGP and increased the accumulation of rhodamine 123, an efflux pump ligand, in brain endothelial cells and the transport of digoxin and verapamil across the BBB model [110]

Figure 7 In the phenylpropanoid biosynthesis pathway, two genes encoding phenylalanine ammonia-lyase ( PAL ) and 4-coumarate-CoA ligase ( 4CL ) were upregulated, four genes encoding -glucosidase were upregulated and one gene was downregulated, nine genes encoding peroxidase ( POD ) were upregulated and seven genes were downregulated, and the metabolites p-coumaric acid and ferulic acid were upregulated under drought stress