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Endocrine factors Changes in body mass and composition cause changes in several tonic hormones implicated in bone metabolism and health

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(1999b)

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Arch Toxicol 85:13951405

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this pathway will, in turn, upregulate pro-fibrogenic matrix metalloproteinase-2 (MMP2) and downregulate matrix metalloproteinase-1 (MMP1), two enzymes responsible for remodeling the hepatic extracellular matrix [9, 191, 192, 216]

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