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HERMES addresses one significant limitation of edited MRS the extended scan times required to make multiple single-metabolite measurements

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88 In these experiments, we identified a window where drug metabolism and NAPQI formation were completed, but GSH could still effectively protect due to its scavenging of peroxynitrite, suggesting that this oxidant is critical for APAP-induced liver injury

The accumulation of uncleared ROS leads to oxidation of the phospholipid membrane, membrane proteins, and DNA, thereby damaging cellular structure and function, producing significant amounts of Malondialdehyde (MDA), which exacerbates myocardial injury and promotes myocardial I/R injury
