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[DOI] [PMC free article] [PubMed] [Google Scholar] 545.Sayadi A, Nguyen AT, Bard FA, Bard-Chapeau EA

These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

Kalucka J, de Rooij LPMH, Goveia J, et al

By delineating curcumins activation of Sirt3/FoxO3a signaling as a central mechanism mitigating oxidative stress and enhancing osteogenic differentiation, this research advances the therapeutic toolkit for diabetic osteoporosis