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The inhibition of autophagy may allow an imbalance in NRF 2 -mediated metabolism as well as redox regulation, which increases iron deposition and lipid peroxidation, promoting cardiomyocyte ferroptosis and the progression of T1DM cardiomyopathy (79)

It helps in the production and activation of immune cells, enhancing the body's ability to fight infections

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Women with positive TPO antibodies and currently normal thyroid function who become pregnant require close thyroid monitoring throughout pregnancy TSH can rise significantly in the first trimester when thyroid hormone demands increase, and women with Hashimotos who were previously euthyroid may develop hypothyroidism requiring treatment during pregnancy