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University of Toronto, Masters thesis.
Folate insufficiency was one of these three variables that had the most impact on the serum tHcy levels, followed by MTHFR C677T and vitamin B12 deficiency (in decreasing order of impact) [48]
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Furthermore, the patients response to methylprednisolone treatment and the findings of scattered unidentified bright objects (UBOs) on brain MRI are more suggestive of a demyelinating process than a nutritional deficiency
