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The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation
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World J Gastroenterol 23:4658488 Farges M, Balcerzak D, Fisher B, Attaix D, Bchet D, Ferrara M, Baracos V (2002) Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis
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