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Many former employees reported that company sales goals were impossible to meet, and incentives for compensation and ongoing employment encouraged gaming the system
Endogenous opiates and behavior: 2023

It is not FDA-approved, and no standardized medical dosing protocol exists

The reduction in total drug delivered to the systemic circulation is referred to as the First Pass Effect - reflecting the loss of drug via its first pass thru the GI tissues & liver before it reaches the systemic circulation
