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Swirl gently never shake, which fractures peptide chains

In other words, the post-translational maturation appears to be hampered in the mutant SOD1 proteins, resulting in an increased propensity of SOD1 to misfold into oligomers and aggregates
10.1007/s11738-011-0881-y 80 Roy ChoudhuryA.DasK.GhoshS.MukherjeeR